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The U.S. Food and Drug Administration (FDA) has issued an Emergency Use Authorization (EUA) to make PAXLOVID available for the treatment of COVID-19 in certain patients.

PAXLOVID

PAXLOVID is authorized for emergency use

  • PAXLOVID has not been approved, but has been authorized for emergency use by FDA under an EUA, for the treatment of mild-to-moderate COVID-19 in pediatric patients (12 years of age and older weighing at least 40 kg) who are at high risk for progression to severe COVID-19, including hospitalization or death.
  • The emergency use of PAXLOVID is only authorized for the duration of the declaration that circumstances exist justifying the authorization of the emergency use of drugs and biological products during the COVID-19 pandemic under Section 564(b)(1) of the Act, 21 U.S.C. § 360bbb-3(b)(1), unless the declaration is terminated or authorization revoked sooner.

Getting PAXLOVID

Think PAXLOVID is right for you? Follow these steps:

1

Know if you are at high risk for progression to severe COVID-19

Your risk of getting severely ill with COVID-19 is increased by many health conditions, lifestyle factors, disabilities, and more. Some of the more common high-risk factors include:

  • Age of 50+ years
  • Certain health conditions and diseases, such as heart disease and diabetes
  • Being overweight or obese
  • Mental health conditions
  • Lifestyle factors, such as smoking
  • Physical, mental, and developmental disabilities
2

As soon as you notice symptoms of COVID-19, reach out to your healthcare professional. They may test you for COVID-19

Symptoms may include, but are not limited to:

  • Fever or chills
  • Cough
  • Shortness of breath or difficulty breathing
  • Fatigue
  • Muscle or body aches
  • Headache
  • New loss of taste or smell
  • Sore throat
  • Congestion or runny nose
  • Nausea or vomiting
  • Diarrhea
Safety

Testing is important. Need help finding a test? See testing resources.

3

Work with your healthcare professional to get prescribed PAXLOVID, if appropriate

Once you fill your prescription, start taking PAXLOVID that morning or evening, or at the time your healthcare professional recommends. Remember, PAXLOVID must be started within the first 5 days of COVID-19 symptoms.

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Don’t have or can’t connect with a healthcare professional? PAXLOVID can also be prescribed at a Test to Treat site,* by urgent care providers and state-licensed pharmacists, or by a telehealth provider. These resources may help.

*By clicking this link, you will be redirected to a website that is neither owned nor controlled by Pfizer. Pfizer is not responsible for the content or services of this site.

Your pharmacist will need to know all the prescription and over-the-counter medications you take and review your medical records from the last year, including laboratory blood work results. You can print these records, send them electronically, or ask your regular physician’s office to send them directly to the pharmacy.

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Get ready to talk to your healthcare professional about PAXLOVID.

Download the COVID-19 Preparedness Plan

Find a COVID-19 test

Getting-PAXLOVID

Testing for COVID-19 can help your healthcare professional diagnose you. These links or your healthcare professional can help you find testing. Any FDA-authorized COVID-19 test can be used, including at-home tests.

  • Test to Treat is a government initiative that offers one-stop testing and treatment for COVID-19 (if appropriate). Locations are available nationwide
  • Covidtests.gov is a government-sponsored resource that can help you find free testing options, information about insurance reimbursement for testing, and more
  • Abbott is a producer of at-home tests, and offers tools to help you find a test kit locally or online
  • Quidel is a producer of at-home tests that are available at many local and online retailers

This is not an exhaustive list of COVID-19 testing options. Pfizer does not own or operate any of the listed websites, or the products that they furnish, and Pfizer accepts no responsibility or liability for them.

By clicking this link, you will be redirected to a website that is neither owned nor controlled by Pfizer. Pfizer is not responsible for the content or services of this site.

Connect with a healthcare professional

Safety

If you have mild-to-moderate COVID-19 symptoms, suspect you have COVID-19, and are at high risk, it’s important to reach out to your healthcare professional immediately. If you don’t have a healthcare professional or your healthcare professional isn’t available, these resources may help you connect with an in-person or telehealth provider.

Pfizer does not own, operate, or endorse any of these telehealth platforms, or the services they or their providers may furnish, and Pfizer accepts no responsibility or liability for them.

Telehealth vendors were selected based on their ability to provide services via telehealth. Neither the providers nor the telehealth platforms pay a fee to Pfizer for inclusion on this website.

If these telehealth platforms match users with providers, the selection of a particular provider is determined by the criteria set by the platform and/or provider, not Pfizer. All treatment decisions are at the sole discretion of the provider based on the patient’s individual needs and risk-benefit profile.

Test to Treat§ is a government initiative that offers one-stop testing and treatment for COVID-19 (if appropriate). Locations are available nationwide.

Other options include these telehealth services, where you can connect with a healthcare professional by phone, chat, or video§:

§By clicking this link, you will be redirected to a website that is neither owned nor controlled by Pfizer. Pfizer is not responsible for the content or services of this site.

||By clicking this link, you will be redirected to a website that is owned and controlled by a third party, Ada Health Inc. Pfizer Inc. has contracted with Ada Health Inc. for the development, hosting, and operation of this platform.

Prescribed PAXLOVID?

Learn how to take PAXLOVID
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Important Safety Information

Expand

Significant Drug Interactions. PAXLOVID can interact with other medicines, causing severe or life-threatening side effects or death. Do not take PAXLOVID if you are taking any of the following medicines:

  • alfuzosin
  • amiodarone
  • apalutamide
  • carbamazepine
  • colchicine
  • dihydroergotamine
  • dronedarone
  • eletriptan
  • eplerenone
  • ergotamine
  • finerenone
  • flecainide
  • flibanserin
  • ivabradine
  • lomitapide
  • lovastatin
  • lumacaftor/ivacaftor
  • lurasidone
  • methylergonovine
  • midazolam (oral)
  • naloxegol
  • phenobarbital
  • phenytoin
  • pimozide
  • primidone
  • propafenone
  • quinidine
  • ranolazine
  • rifampin
  • rifapentine
  • St. John’s Wort (hypericum perforatum)
  • sildenafil (Revatio®) for pulmonary arterial hypertension
  • silodosin
  • simvastatin
  • tolvaptan
  • triazolam
  • ubrogepant
  • voclosporin

These are not the only medicines that may cause serious or life-threatening side effects if taken with PAXLOVID. PAXLOVID may increase or decrease the levels of other medicines. It is very important to tell your healthcare professional about all the medicines you are taking, including prescription and over-the-counter medicines, vitamins, and herbal supplements, because additional laboratory tests or changes in the dose of your other medicines may be necessary during treatment with PAXLOVID. Your healthcare professional may also tell you about specific symptoms to watch out for that may indicate that you need to stop or decrease the dose of some of your other medicines. Do not start taking a new medicine without telling your healthcare professional.

Before taking PAXLOVID, tell your healthcare professional about all your medical conditions, including if you:

  • have kidney or liver problems, including hepatitis.
  • have Human Immunodeficiency Virus 1 (HIV-1) infection. PAXLOVID may lead to some
    HIV-1 medicines not working as well in the future.
  • are pregnant, plan to become pregnant, breastfeeding, or plan to breastfeed.

Tell your healthcare professional if you are taking combined hormonal contraceptive (birth control). PAXLOVID may affect how your birth control works. People who can become pregnant should use another or an alternative effective form of birth control.

PAXLOVID may cause serious side effects, including:

  • Allergic reactions, including severe allergic reactions (anaphylaxis). Do not take PAXLOVID if you are allergic to nirmatrelvir, ritonavir, or any of the ingredients in PAXLOVID. Stop taking PAXLOVID and call your healthcare professional right away if you get any of the following symptoms of an allergic reaction:

    • skin rash, hives, blisters, or peeling skin
    • painful sores or ulcers in the mouth, nose, throat, or genital area
    • trouble swallowing or breathing
    • swelling of the mouth, lips, tongue, or face
    • hoarseness
    • throat tightness
  • Liver problems. Tell your healthcare professional right away if you have any of the following signs and symptoms of liver problems during treatment with PAXLOVID:

    • loss of appetite
    • yellowing of your skin and the whites of your eyes
    • dark-colored urine
    • pale-colored stools
    • itchy skin
    • stomach-area (abdominal) pain

The most common side effects of PAXLOVID include: altered sense of taste and diarrhea.

Other possible side effects include:

  • headache
  • abdominal pain
  • vomiting
  • high blood pressure
  • nausea
  • feeling generally unwell

These are not all the possible side effects of PAXLOVID. For more information, ask your
healthcare professional or pharmacist.



There is no experience treating pregnant women or breastfeeding mothers with PAXLOVID.
For a mother and unborn baby, the benefit of taking PAXLOVID may be greater than the risk
from the treatment. It is recommended that you use effective barrier contraception or do not
have sexual activity while taking PAXLOVID. If you are pregnant or breastfeeding, discuss
your options and specific situation with your healthcare professional.



Take PAXLOVID exactly as your healthcare professional tells you. If you take too much PAXLOVID, call your healthcare professional or go to the nearest hospital emergency room right away. If you are taking a ritonavir- or cobicistat-containing medicine to treat hepatitis C or HIV-1 infection, you should continue to take your medicine as prescribed.



Talk to your healthcare professional if you do not feel better or if you feel worse after 5 days.


Please see Fact Sheet for Healthcare Providers and Fact Sheet for Patients, Parents, and Caregivers.

AUTHORIZED USE

The FDA has authorized the emergency use of PAXLOVID for the treatment of mild-to-moderate COVID-19 in adults and children (12 years of age and older weighing at least 88 pounds [40 kg]) who are at high risk for progression to severe COVID-19, including hospitalization or death, under an EUA.

PAXLOVID use in children is still being studied. There is limited information about the safety and effectiveness of PAXLOVID to treat children with mild-to-moderate COVID-19.


Please see Fact Sheet for Healthcare Providers and Fact Sheet for Patients, Parents, and Caregivers.

AUTHORIZED USE

The FDA has authorized the emergency use of PAXLOVID for the treatment of mild-to-moderate COVID-19 in adults and children (12 years of age and older weighing at least 88 pounds [40 kg]) who are at high risk for progression to severe COVID-19, including hospitalization or death, under an EUA.

PAXLOVID use in children is still being studied. There is limited information about the safety and effectiveness of PAXLOVID to treat children with mild-to-moderate COVID-19.


Please see Fact Sheet for Healthcare Providers and Fact Sheet for Patients, Parents, and Caregivers.

Important Safety Information

Significant Drug Interactions. PAXLOVID can interact with other medicines, causing severe or life-threatening side effects or death. Do not take PAXLOVID if you are taking any of the following medicines:

  • alfuzosin
  • amiodarone
  • apalutamide
  • carbamazepine
  • colchicine
  • dihydroergotamine
  • dronedarone
  • eletriptan
  • eplerenone
  • ergotamine
  • finerenone
  • flecainide
  • flibanserin
  • ivabradine
  • lomitapide
  • lovastatin
  • lumacaftor/ivacaftor
  • lurasidone
  • methylergonovine
  • midazolam (oral)
  • naloxegol
  • phenobarbital
  • phenytoin
  • pimozide
  • primidone
  • propafenone
  • quinidine
  • ranolazine
  • rifampin
  • rifapentine
  • St. John’s Wort (hypericum perforatum)
  • sildenafil (Revatio®) for pulmonary arterial hypertension
  • silodosin
  • simvastatin
  • tolvaptan
  • triazolam
  • ubrogepant
  • voclosporin

These are not the only medicines that may cause serious or life-threatening side effects if taken with PAXLOVID. PAXLOVID may increase or decrease the levels of other medicines. It is very important to tell your healthcare professional about all the medicines you are taking, including prescription and over-the-counter medicines, vitamins, and herbal supplements, because additional laboratory tests or changes in the dose of your other medicines may be necessary during treatment with PAXLOVID. Your healthcare professional may also tell you about specific symptoms to watch out for that may indicate that you need to stop or decrease the dose of some of your other medicines. Do not start taking a new medicine without telling your healthcare professional.

Before taking PAXLOVID, tell your healthcare professional about all your medical conditions, including if you:

  • have kidney or liver problems, including hepatitis.
  • have Human Immunodeficiency Virus 1 (HIV-1) infection. PAXLOVID may lead to some HIV-1 medicines not working as well in the future.
  • are pregnant, plan to become pregnant, breastfeeding, or plan to breastfeed.

Tell your healthcare professional if you are taking combined hormonal contraceptive (birth control). PAXLOVID may affect how your birth control works. People who can become pregnant should use another or an alternative effective form of birth control.

PAXLOVID may cause serious side effects, including:

  • Allergic reactions, including severe allergic reactions (anaphylaxis). Do not take PAXLOVID if you are allergic to nirmatrelvir, ritonavir, or any of the ingredients in PAXLOVID. Stop taking PAXLOVID and call your healthcare professional right away if you get any of the following symptoms of an allergic reaction:

    • skin rash, hives, blisters, or peeling skin
    • painful sores or ulcers in the mouth, nose, throat, or genital area
    • trouble swallowing or breathing
    • swelling of the mouth, lips, tongue, or face
    • hoarseness
    • throat tightness
  • Liver problems. Tell your healthcare professional right away if you have any of the following signs and symptoms of liver problems during treatment with PAXLOVID:

    • loss of appetite
    • yellowing of your skin and the whites of your eyes
    • dark-colored urine
    • pale-colored stools
    • itchy skin
    • stomach-area (abdominal) pain

The most common side effects of PAXLOVID include: altered sense of taste and diarrhea.

Other possible side effects include:

  • headache
  • abdominal pain
  • vomiting
  • high blood pressure
  • nausea
  • feeling generally unwell

These are not all the possible side effects of PAXLOVID. For more information, ask your
healthcare professional or pharmacist.



There is no experience treating pregnant women or breastfeeding mothers with PAXLOVID. For a mother and unborn baby, the benefit of taking PAXLOVID may be greater than the risk from the treatment. It is recommended that you use effective barrier contraception or do not have sexual activity while taking PAXLOVID. If you are pregnant or breastfeeding, discuss your options and specific situation with your healthcare professional.



Take PAXLOVID exactly as your healthcare professional tells you. If you take too much PAXLOVID, call your healthcare professional or go to the nearest hospital emergency room right away. If you are taking a ritonavir- or cobicistat-containing medicine to treat hepatitis C or HIV-1 infection, you should continue to take your medicine as prescribed.



Talk to your healthcare professional if you do not feel better or if you feel worse after 5 days.



Please see Fact Sheet for Healthcare Providers and Fact Sheet for Patients, Parents, and Caregivers.

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AUTHORIZED USE

The FDA has authorized the emergency use of PAXLOVID for the treatment of mild-to-moderate COVID-19 in adults and children (12 years of age and older weighing at least 88 pounds [40 kg]) who are at high risk for progression to severe COVID-19, including hospitalization or death, under an EUA.

PAXLOVID use in children is still being studied. There is limited information about the safety and effectiveness of PAXLOVID to treat children with mild-to-moderate COVID-19.