Important topics to cover with your healthcare professional
Talk to your healthcare professional about your medical conditions and review your recent medical records together
This will help your healthcare professional determine if PAXLOVID is right for you, if you need a different dose of PAXLOVID, or if you need to stop or change the dose of any other medicines you take.
You can help prepare for this discussion by knowing if you:
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Have any allergies (do not take PAXLOVID if you are allergic to nirmatrelvir, ritonavir, or any of the other ingredients in PAXLOVID)
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Have liver or kidney disease (bring your latest lab results, if possible)
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Are pregnant, plan to become pregnant, or are breastfeeding. It is not known if PAXLOVID is safe to take during pregnancy or while breastfeeding, so be sure to discuss this with your healthcare professional
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Have any serious illnesses
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Take a hormonal birth control medicine. PAXLOVID can affect how some birth controls work, so be sure to ask your healthcare professional if you need to use a different or an additional form of contraception
It is very important to come with a list of all the medicines you take, including over-the-counter and prescription medicines, vitamins, and herbal supplements
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PAXLOVID may strengthen or weaken multiple other medicines. Taking PAXLOVID with certain medicines may cause serious life-threatening side effects or affect how PAXLOVID works. It is critical to tell your healthcare professional about all of the medicines you are taking, including herbal supplements, because taking certain laboratory tests or changing the dose of your other medicines or supplements may be necessary
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Don’t start any new medications without discussing with your healthcare professional
Some medications cannot be taken with PAXLOVID
The table below is not a complete list of all medicines that cannot be taken with PAXLOVID. There are other medicines that may need to be stopped temporarily. Speak to your healthcare professional about all medicines you are taking, not just those listed below. Taking certain medicines with PAXLOVID may result in serious, life-threatening reactions.
Medicine name |
Common brand name(s) |
Common conditions treated* |
---|---|---|
Alfuzosin |
Uroxatral® |
Enlarged prostate |
Ranolazine |
Ranexa® |
Chronic chest pain (angina) |
Amiodarone |
Pacerone®, Cordarone® |
Irregular heartbeat (arrhythmia) |
Dronedarone |
Multaq® |
Irregular heartbeat (arrhythmia) |
Flecainide |
Tambocor® |
Irregular heartbeat (arrhythmia) |
Propafenone |
Rythmol SR® |
Irregular heartbeat (arrhythmia) |
Quinidine |
Irregular heartbeat (arrhythmia) |
|
Colchicine |
Mitigare®, Colcrys® |
Gout attacks |
Lurasidone |
Latuda® |
Schizophrenia |
Pimozide |
Orap® |
Tourette syndrome |
Dihydroergotamine |
Migraine and cluster headaches |
|
Ergotamine |
Cafergot® |
Migraine |
Methylergonovine |
Methergine® |
Severe bleeding after childbirth or an abortion |
Lovastatin |
Altoprev® |
High cholesterol |
Simvastatin |
Zocor®, FloLipid® |
High cholesterol and triglyceride levels |
Sildenafil |
Revatio® |
Pulmonary arterial hypertension |
Triazolam |
Halcion® |
Insomnia (sleep disorder) |
Oral midazolam |
Versed® |
Anxiety before a medical procedure |
Apalutamide |
Erleada® |
Prostate cancer |
Carbamaze Carbamazepine |
Tegretol XR®, Tegretol®, Carbatrol® |
Epilepsy/seizures, nerve pain, bipolar disorder |
Phenobarbital |
Luminal® |
Seizures, anxiety, withdrawal from another barbiturate medication |
Phenytoin |
Phenytek®, Dilantin® |
Seizures |
Rifampin |
Rifadin® |
Tuberculosis |
St. John’s wort |
A wide range of uses such as depression and wounds |
*Some medicines may be taken off-label. Brand names are registered trademarks of their respective owners.
Get the most out of your conversation with your healthcare professional by coming prepared.
Download the COVID-19 Preparedness Plan
Possible Side Effects
PAXLOVID may cause side effects, some of which may be severe. Some medicines may interact with PAXLOVID and may cause serious side effects. Tell your healthcare professional about all the medicines you take, and tell them if you experience any side effects while taking PAXLOVID.
Some side effects of PAXLOVID are:
Allergic Reactions
Stop taking PAXLOVID and call your healthcare professional right away if you get any of the following symptoms of an allergic reaction:
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Hives, skin rash
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Trouble swallowing or breathing
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Swelling of the mouth, lips, or face
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Throat tightness
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Hoarseness of voice
Liver Problems
Tell your healthcare professional right away if you have any of these signs and symptoms of liver problems:
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Loss of appetite
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Yellowing of your skin and the whites of your eyes (jaundice)
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Dark-colored urine
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Pale-colored stools and itchy skin
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Stomach area (abdominal) pain
Resistance to HIV Medicines
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If you have untreated human immunodeficiency virus (HIV) infection, PAXLOVID may lead to some HIV medicines not working as well in the future
Other Possible Side Effects
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Change in sense of taste
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Diarrhea
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High blood pressure
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Muscle aches
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Stomach area (abdominal) pain
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Nausea
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Generally feeling unwell (malaise)
These are not all the possible side effects of
Patients should always ask their doctors for medical advice about adverse events. You are encouraged to report adverse events related to Pfizer products by calling
For more information, please see Fact Sheet for Healthcare Providers and Fact Sheet for Patients, Parents, and Caregivers.
†By clicking this link, you will be redirected to a website that is neither owned nor controlled by Pfizer. Pfizer is not responsible for the content of this site or service.

PAXLOVID
can help treat mild-to-moderate COVID-19 in people with certain high-risk factors.
Learn who can take PAXLOVID
